Lack of Specific Regulatory T Cell Depletion and Cytoreduction Associated with Extensive Toxicity After Administration of Low and High Doses of Cyclophosphamide-Reference-Cited by-同舟云学术

Lack of Specific Regulatory T Cell Depletion and Cytoreduction Associated with Extensive Toxicity After Administration of Low and High Doses of Cyclophosphamide

Published:2022-01-01 Issue:1 Volume:38 Page:45-49
ISSN:0889-2229
Container-title:AIDS Research and Human Retroviruses
language:en
Short-container-title:AIDS Research and Human Retroviruses

Author:

Kleinman Adam J.¹,Sivanandham Ranjit¹²,Sette Paola¹²,Brocca-Cofano Egidio²,McAndrews Colin²,Keele Brandon F.³,Pandrea Ivona²⁴,Apetrei Cristian¹⁴^ORCID

Affiliation:

1. Division of Infectious Diseases, DOM, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.

2. Department of Pathology, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.

3. AIDS and Cancer Virus Program, Frederick National Laboratory for Cancer Research, Frederick, Maryland, USA.

4. Department of Infectious Diseases and Immunology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.

Publisher

Mary Ann Liebert Inc

Subject

Infectious Diseases,Virology,Immunology

Link

https://www.liebertpub.com/doi/pdf/10.1089/aid.2021.0036

Reference16 articles.

1. Metronomic cyclophosphamide regimen selectively depletes CD4+CD25+ regulatory T cells and restores T and NK effector functions in end stage cancer patients

2. Cutting Edge: T Regulatory Cell Depletion Reactivates Latent Simian Immunodeficiency Virus (SIV) in Controller Macaques While Boosting SIV-Specific T Lymphocytes

3. Nonhuman Primate Testing of the Impact of Different Regulatory T Cell Depletion Strategies on Reactivation and Clearance of Latent Simian Immunodeficiency Virus

4. Treatment of AIDS-related non-Hodgkin’s lymphoma with chemotherapy (CNOP) and r-hu-G-CSF: Clinical outcome and effect on HIV-1 viral load

5. Addition of Cyclophosphamide to Antiretroviral Therapy Does Not Diminish the Cellular Reservoir in HIV-Infected Persons

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