Investigation of Ocular Events Associated with Taprenepag Isopropyl, a Topical EP2 Agonist in Development for Treatment of Glaucoma-Reference-Cited by-同舟云学术

Investigation of Ocular Events Associated with Taprenepag Isopropyl, a Topical EP2 Agonist in Development for Treatment of Glaucoma

Published:2014-06 Issue:5 Volume:30 Page:429-439
ISSN:1080-7683
Container-title:Journal of Ocular Pharmacology and Therapeutics
language:en
Short-container-title:Journal of Ocular Pharmacology and Therapeutics

Author:

Yanochko Gina M.¹,Affolter Timothy¹,Eighmy Johnnie J.²,Evans Mark G.¹,Khoh-Reiter Su¹,Lee Dong¹,Miller Paul E.³,Shiue Michael H. I.⁴,Trajkovic Dusko¹,Jessen Bart A.¹

Affiliation:

1. Drug Safety Research & Development, Pfizer, Inc., San Diego, California.

2. Covance Laboratories, Inc., Madison, Wisconsin.

3. Comparative Ophthalmic Research Laboratory, University of Wisconsin Veterinary Medical Teaching Hospital, Madison, Wisconsin.

4. Pharmacokinetics, Dynamics & Metabolism, Pfizer, Inc., San Diego, California.

Publisher

Mary Ann Liebert Inc

Subject

Pharmacology (medical),Pharmacology,Ophthalmology

Link

http://www.liebertpub.com/doi/pdf/10.1089/jop.2013.0222

Reference22 articles.

1. A Phase 2, Randomized, Dose-Response Trial of Taprenepag Isopropyl (PF-04217329) Versus Latanoprost 0.005% in Open-Angle Glaucoma and Ocular Hypertension

2. Effect of PF-04217329 a prodrug of a selective prostaglandin EP2 agonist on intraocular pressure in preclinical models of glaucoma

3. Evaluation of the cytotoxic effects of ophthalmic solutions containing benzalkonium chloride on corneal epithelium using an organotypic 3-D model

4. Comparison of preservative-induced toxicity on monolayer and stratified Chang conjunctival cells

5. IL-6 switches the differentiation of monocytes from dendritic cells to macrophages

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