Characterization and Optimization of a Novel Protein–Protein Interaction Biosensor High-Content Screening Assay to Identify Disruptors of the Interactions Between p53 and hDM2-Reference-Cited by-同舟云学术

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Characterization and Optimization of a Novel Protein–Protein Interaction Biosensor High-Content Screening Assay to Identify Disruptors of the Interactions Between p53 and hDM2

Published:2010-08 Issue:4 Volume:8 Page:437-458
ISSN:1540-658X
Container-title:ASSAY and Drug Development Technologies
language:en
Short-container-title:ASSAY and Drug Development Technologies

Author:

Dudgeon Drew D.¹²,Shinde Sunita N.¹,Shun Tong Ying¹,Lazo John S.¹²,Strock Christopher J.³,Giuliano Kenneth A.³,Taylor D. Lansing³,Johnston Patricia A.³,Johnston Paul A.¹²

Affiliation:

1. Drug Discovery Institute, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania.

2. Department of Pharmacology and Chemical Biology, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania.

3. Cellumen, Inc., Pittsburgh, Pennsylvania.

Publisher

Mary Ann Liebert Inc

Subject

Drug Discovery,Molecular Medicine

Link

http://www.liebertpub.com/doi/pdf/10.1089/adt.2010.0281

Reference57 articles.

1. High-Throughput Screening Assays to Discover Small-Molecule Inhibitors of Protein Interactions

2. Molecular and cellular approaches for the detection of protein-protein interactions: latest techniques and current limitations

3. Emerging classes of protein–protein interaction inhibitors and new tools for their development

4. Universal Screening Methods and Applications of ThermoFluor®

5. Mammalian two-hybrids come of age

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