Preclinical Pharmacokinetics in Tumors and Normal Tissues of the Antigene PNA Oligonucleotide MYCN-Inhibitor BGA002-Reference-Cited by-同舟云学术

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Preclinical Pharmacokinetics in Tumors and Normal Tissues of the Antigene PNA Oligonucleotide MYCN-Inhibitor BGA002

Published:2024-08-01 Issue:4 Volume:34 Page:173-187
ISSN:2159-3337
Container-title:Nucleic Acid Therapeutics
language:en
Short-container-title:Nucleic Acid Therapeutics

Author:

Scardovi Anna Lisa¹,Bartolucci Damiano¹^ORCID,Montemurro Luca²^ORCID,Bortolotti Sonia¹^ORCID,Angelucci Silvia¹,Amadesi Camilla¹,Nieddu Giammario¹,Oosterholt Sean³,Cerisoli Lucia¹,Della Pasqua Oscar³,Hrelia Patrizia⁴,Tonelli Roberto⁴^ORCID

Affiliation:

1. R&D Department, BIOGENERA SpA, Bologna, Italy.

2. AGEOP Ricerca OdV, IRCCS S. Orsola Hospital, Pediatric Oncology and Hematology Unit, Bologna, Italy.

3. Clinical Pharmacology & Therapeutics Group, University College London, London, United Kingdom.

4. Department of Pharmacy and Biotechnologies, University of Bologna, Bologna, Italy.

Publisher

Mary Ann Liebert Inc

Link

https://www.liebertpub.com/doi/pdf/10.1089/nat.2024.0005

Reference46 articles.

1. Targeting MYCN in Pediatric and Adult Cancers

2. A Novel MYCN-Specific Antigene Oligonucleotide Deregulates Mitochondria and Inhibits Tumor Growth in MYCN-Amplified Neuroblastoma

3. MYCN Impact on High-Risk Neuroblastoma: From Diagnosis and Prognosis to Targeted Treatment

4. Antitumor Activity of Sustained N-Myc Reduction in Rhabdomyosarcomas and Transcriptional Block by Antigene Therapy

5. Integrative genome analyses identify key somatic driver mutations of small-cell lung cancer

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