The Inwardly Rectifying Potassium Channel Kir1.1: Development of Functional Assays to Identify and Characterize Channel Inhibitors-Reference-Cited by-同舟云学术

The Inwardly Rectifying Potassium Channel Kir1.1: Development of Functional Assays to Identify and Characterize Channel Inhibitors

Published:2012-10 Issue:5 Volume:10 Page:417-431
ISSN:1540-658X
Container-title:ASSAY and Drug Development Technologies
language:en
Short-container-title:ASSAY and Drug Development Technologies

Author:

Felix John P.¹,Priest Birgit T.¹,Solly Kelli²,Bailey Timothy¹,Brochu Richard M.¹,Liu Chou J.¹,Kohler Martin G.¹,Kiss Laszlo²,Alonso-Galicia Magdalena³,Tang Haifeng⁴,Pasternak Alexander⁴,Kaczorowski Gregory J.¹,Garcia Maria L.¹

Affiliation:

1. Department of Ion Channels, Merck Research Laboratories, North Wales, Pennsylvania.

2. Department of Automated Biotechnology, Merck Research Laboratories, North Wales, Pennsylvania.

3. Department of Hypertension, Merck Research Laboratories, North Wales, Pennsylvania.

4. Department of Medicinal Chemistry, Merck Research Laboratories, Rahway, New Jersey.

Publisher

Mary Ann Liebert Inc

Subject

Drug Discovery,Molecular Medicine

Link

http://www.liebertpub.com/doi/pdf/10.1089/adt.2012.462

Reference29 articles.

1. Inward rectification of a potassium channel in cardiac ventricular cells depends on internal magnesium ions.

2. Potassium channel block by cytoplasmic polyamines as the mechanism of intrinsic rectification

3. INWARD RECTIFIER POTASSIUM CHANNELS

4. Crystal Structure of the Eukaryotic Strong Inward-Rectifier K + Channel Kir2.2 at 3.1 Å Resolution

5. Intracellular regulation of inward rectifier K+ channels

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