Safety, Biodistribution, and Efficacy of an AAV-5 Vector Encoding Human Interferon-Beta (ART-I02) Delivered via Intra-Articular Injection in Rhesus Monkeys with Collagen-Induced Arthritis-Reference-Cited by-同舟云学术

Safety, Biodistribution, and Efficacy of an AAV-5 Vector Encoding Human Interferon-Beta (ART-I02) Delivered via Intra-Articular Injection in Rhesus Monkeys with Collagen-Induced Arthritis

Published:2015-06 Issue:2 Volume:26 Page:103-112
ISSN:2324-8637
Container-title:Human Gene Therapy Clinical Development
language:en
Short-container-title:Human Gene Therapy Clinical Development

Author:

Bevaart Lisette¹,Aalbers Caroline J.¹²,Vierboom Michel P.M.³,Broekstra Niels¹,Kondova Ivanela³,Breedveld Elia³,Hauck Bernd⁴,Wright J. Fraser⁴,Tak Paul Peter¹²,Vervoordeldonk Margriet J.¹²

Affiliation:

1. Arthrogen B.V., Amsterdam 1105 BA, The Netherlands.

2. Division of Clinical Immunology and Rheumatology, Academic Medical Center/University of Amsterdam, 1105 AZ, The Netherlands.

3. Department of Immunobiology, Biomedical Primate Research Centre, Rijswijk 2288 GH, The Netherlands.

4. Center for Cellular and Molecular Therapeutics, Children's Hospital of Philadelphia, Philadelphia, PA 19104.

Publisher

Mary Ann Liebert Inc

Subject

Genetics(clinical)

Link

http://www.liebertpub.com/doi/pdf/10.1089/humc.2015.009

Reference40 articles.

1. Development of anti-TNF therapy for rheumatoid arthritis

2. Evolving concepts of rheumatoid arthritis

3. Gene therapy as a therapeutic approach for the treatment of rheumatoid arthritis: innovative vectors and therapeutic genes

4. Enhanced gene transfer to arthritic joints using adeno-associated virus type 5: implications for intra-articular gene therapy

5. Adeno-Associated Virus Pseudotype 5 Vector Improves Gene Transfer in Arthritic Joints

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