Examining Ligand-Based Stabilization of Proteins in Cells with MEK1 Kinase Inhibitors
Author:
Affiliation:
1. Novartis Institutes for Biomedical Research, Center for Proteomic Chemistry, Cambridge, Massachusetts.
2. AstraZeneca, R&D, Innovative Medicines, Macclesfield, Cheshire, United Kingdom.
Publisher
Mary Ann Liebert Inc
Subject
Drug Discovery,Molecular Medicine
Link
http://www.liebertpub.com/doi/pdf/10.1089/adt.2014.614
Reference21 articles.
1. On the nature of allosteric transitions: A plausible model
2. Thermofluor-based high-throughput stability optimization of proteins for structural studies
3. Thermodynamic Stability of Carbonic Anhydrase: Measurements of Binding Affinity and Stoichiometry Using ThermoFluor
4. A high-throughput fluorescence chemical denaturation assay as a general screen for protein–ligand binding
5. A Specific Mechanism for Nonspecific Activation in Reporter-Gene Assays
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