Why Are Patients Switching from Tenofovir Disoproxil Fumarate/Emtricitabine (Truvada) to Tenofovir Alafenamide/Emtricitabine (Descovy) for Pre-Exposure Prophylaxis?

Author:

D'Angelo Alexa B.12ORCID,Westmoreland Drew A.2,Carneiro Pedro B.1ORCID,Johnson Jeremiah3,Grov Christian12

Affiliation:

1. CUNY Graduate School of Public Health and Health Policy, New York, New York, USA.

2. CUNY Institute for Implementation Science in Population Health, New York, New York, USA.

3. Treatment Action Group, New York, New York, USA.

Publisher

Mary Ann Liebert Inc

Subject

Infectious Diseases,Public Health, Environmental and Occupational Health

Reference36 articles.

1. 1. CDC. US Public Health Service: Preexposure Prophylaxis for the Prevention of HIV Infection in the United States—2017 Update: A Clinical Practice Guideline. Atlanta, GA: U.S. Department of Health and Human Services, 2018.

2. FDA paves the way for pre-exposure HIV prophylaxis

3. 7. Hare C, Coll J, Ruane P, et al. The phase 3 DISCOVER study: Daily F/TAF or F/TDF for HIV preexposure prophylaxis. In: Paper presented at: Conference on retroviruses and opportunistic infections, Seattle, Washington, March 4–7, 2019.

4. 8. Spinner C, Brunetta J, Shalit P, et al. DISCOVER study for HIV pre-exposure prophylaxis (PrEP): F/TAF has a more rapid onset and longer sustained duration of HIV protection compared with F/TDF. In: Paper presented at: The International AIDS Conference, Mexico City, Mexico, July 21–24, 2019.

5. Emtricitabine and tenofovir alafenamide vs emtricitabine and tenofovir disoproxil fumarate for HIV pre-exposure prophylaxis (DISCOVER): primary results from a randomised, double-blind, multicentre, active-controlled, phase 3, non-inferiority trial

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