Principal Component Analysis of Binding Energies for Single-Point Mutants of hT2R16 Bound to an Agonist Correlate with Experimental Mutant Cell Response-Reference-Cited by-同舟云学术

Principal Component Analysis of Binding Energies for Single-Point Mutants of hT2R16 Bound to an Agonist Correlate with Experimental Mutant Cell Response

Published:2015-01 Issue:1 Volume:22 Page:37-53
ISSN:1066-5277
Container-title:Journal of Computational Biology
language:en
Short-container-title:Journal of Computational Biology

Author:

Chen Derek E.¹,Willick Darryl L.²,Ruckel Joseph B.³,Floriano Wely B.⁴⁵

Affiliation:

1. Biological Sciences Department, California State Polytechnic University Pomona, Pomona, California.

2. SciReal, LLC, Grand Marais, Minnesota.

3. Integral Molecular, Inc., Philadelphia, Pennsylvania.

4. Department of Chemistry, Lakehead University, Thunder Bay, Ontario, Canada.

5. Thunder Bay Regional Research Institute, Thunder Bay, Ontario, Canada.

Publisher

Mary Ann Liebert Inc

Subject

Computational Theory and Mathematics,Computational Mathematics,Genetics,Molecular Biology,Modeling and Simulation

Link

http://www.liebertpub.com/doi/pdf/10.1089/cmb.2014.0192

Reference54 articles.

1. Contributions of cysteine 114 of the human D3 dopamine receptor to ligand binding and sensitivity to external oxidizing agents

2. Identification of Transmembrane Regions Critical for Ligand Binding to the Human D3 Dopamine Receptor Using Various D3/D1 Transmembrane Chimeras

3. Scanning Mutagenesis Identifies Amino Acid Side Chains in Transmembrane Domain 5 of the M1Muscarinic Receptor that Participate in Binding the Acetyl Methyl Group of Acetylcholine

4. Creation of GPCR-based chemical sensors by directed evolution in yeast

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