Demonstration by Two-Color Flow Cytometry That Tyrosine Kinase Activity Is Required for Down-Modulation of the Oncogenic neu Receptor-Reference-Cited by-同舟云学术

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Demonstration by Two-Color Flow Cytometry That Tyrosine Kinase Activity Is Required for Down-Modulation of the Oncogenic neu Receptor

Published:1994-02 Issue:2 Volume:13 Page:193-209
ISSN:1044-5498
Container-title:DNA and Cell Biology
language:en
Short-container-title:DNA and Cell Biology

Author:

BROWN VALERIE I.,SHAH NEELIMA,SMITH ROBERT,HELLMAN MARIA,JARETT LEONARD,MIKAMI YASUNORI,COHEN ERIK,QIAN XIAOLAN,GREENE MARK I.

Publisher

Mary Ann Liebert Inc

Subject

Cell Biology,Genetics,Molecular Biology,General Medicine

Link

http://www.liebertpub.com/doi/pdf/10.1089/dna.1994.13.193

Reference69 articles.

1. Tumor promoter and epidermal growth factor stimulate phosphorylation of the c-erbB-2 gene product in MKN-7 human adenocarcinoma cells.

2. Multiple independent activations of the neu oncogene by a point mutation altering the transmembrane domain of p185

3. The neu oncogene encodes an epidermal growth factor receptor-related protein

4. Increased tyrosine kinase activity associated with the protein encoded by the activated neu oncogene.

5. Down-regulation of the epidermal growth factor receptor in KB cells is due to receptor internalization and subsequent degradation in lysosomes.

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