An Automated Liquid Chromatography-Mass Spectrometry Process to Determine Metabolic Stability Half-Life and Intrinsic Clearance of Drug Candidates by Substrate Depletion-Reference-Cited by-同舟云学术

An Automated Liquid Chromatography-Mass Spectrometry Process to Determine Metabolic Stability Half-Life and Intrinsic Clearance of Drug Candidates by Substrate Depletion

Published:2008-02 Issue:1 Volume:6 Page:121-129
ISSN:1540-658X
Container-title:ASSAY and Drug Development Technologies
language:en
Short-container-title:ASSAY and Drug Development Technologies

Author:

McNaney Colleen A.¹,Drexler Dieter M.¹,Hnatyshyn Serhiy Y.²,Zvyaga Tatyana A.³,Knipe Jay O.⁴,Belcastro James V.³,Sanders Mark²

Affiliation:

1. Pharmaceutical Candidate Optimization – Discovery Analytical Sciences, Bristol-Myers Squibb Company, Wallingford, CT.

2. Pharmaceutical Candidate Optimization – Discovery Analytical Sciences, Bristol-Myers Squibb Company, Princeton, NJ.

3. Applied Biotechnologies – Molecular Biosciences – Lead Discovery and Profiling, Bristol-Myers Squibb Company, Wallingford, CT.

4. Pharmaceutical Candidate Optimization – Metabolism and Pharmcokinetics – Discovery Support, Bristol-Myers Squibb Company, Wallingford, CT.

Publisher

Mary Ann Liebert Inc

Subject

Drug Discovery,Molecular Medicine

Link

http://www.liebertpub.com/doi/pdf/10.1089/adt.2007.103

Reference26 articles.

1. Utility of in vitro drug metabolism data in predicting in vivo metabolic clearance

2. Research and development costs for drugs

3. The Pharmaceutical Industry — Prices and Progress

4. Use of in vitro human metabolism studies in drug development

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