Long-Term Effects of Gene Therapy in a Novel Mouse Model of Human MFRP-Associated Retinopathy-Reference-Cited by-同舟云学术

Long-Term Effects of Gene Therapy in a Novel Mouse Model of Human MFRP-Associated Retinopathy

Published:2019-05 Issue:5 Volume:30 Page:632-650
ISSN:1043-0342
Container-title:Human Gene Therapy
language:en
Short-container-title:Human Gene Therapy

Author:

Chekuri Anil¹,Sahu Bhubanananda¹²,Chavali Venkata Ramana Murthy¹³,Voronchikhina Marina¹,Soto-Hermida Angel¹,Suk John J.¹,Alapati Akhila N.¹,Bartsch Dirk-Uwe¹,Ayala-Ramirez Raul⁴,Zenteno Juan C.⁴⁵,Dinculescu Astra⁶,Jablonski Monica M.⁷,Borooah Shyamanga¹,Ayyagari Radha¹

Affiliation:

1. Shiley Eye Institute, University of California San Diego, La Jolla, California.

2. Department of Ophthalmology and Visual sciences, Kentucky Lions Eye Center, University of Louisville, Louisville, Kentucky.

3. Scheie Eye Institute, Department of Ophthalmology, University of Pennsylvania, Philadelphia, Pennsylvania.

4. Department of Genetics-Research Unit, Institute of Ophthalmology, Conde de Valenciana, Mexico City, Mexico.

5. Department of Biochemistry, Faculty of Medicine, UNAM, Mexico City, Mexico.

6. Department of Ophthalmology, College of Medicine, University of Florida, Gainesville, Florida.

7. Department of Ophthalmology, The University of Tennessee Health Science Center, Hamilton Eye Institute, University of Tennessee, Memphis, Tennessee.

Publisher

Mary Ann Liebert Inc

Subject

Genetics,Molecular Biology,Molecular Medicine

Link

https://www.liebertpub.com/doi/pdf/10.1089/hum.2018.192

Reference38 articles.

1. Extreme hyperopia is the result of null mutations in MFRP, which encodes a Frizzled-related protein

2. Gene Therapy Restores Mfrp and Corrects Axial Eye Length

3. A Novel Mutation Confirms MFRP as the Gene Causing the Syndrome of Nanophthalmos–Renititis Pigmentosa–Foveoschisis–Optic Disk Drusen

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