Culture Expansion in Low-Glucose Conditions Preserves Chondrocyte Differentiation and Enhances Their Subsequent Capacity to Form Cartilage Tissue in Three-Dimensional Culture

Author:

Heywood Hannah K.1,Nalesso Giovanna2,Lee David A.1,Dell'Accio Francesco2

Affiliation:

1. Institute of Bioengineering, School of Engineering and Materials Science, Queen Mary University of London, London, United Kingdom.

2. Centre for Experimental Medicine and Rheumatology, William Harvey Research Institute, Barts and The London, Queen Mary's School of Medicine and Dentistry, London, United Kingdom.

Publisher

Mary Ann Liebert Inc

Subject

General Biochemistry, Genetics and Molecular Biology

Reference53 articles.

1. National Institute for Health and Clinical Excellence. The use of autologous chondrocyte implantation for the treatment of cartilage defects in knee joints. Technology Appraisal 89. National Institute for Health and Clinical Excellence: London, 2005.

2. Autologous Chondrocyte Transplantation

3. Molecular markers predictive of the capacity of expanded human articular chondrocytes to form stable cartilage in vivo

4. Expanded phenotypically stable chondrocytes persist in the repair tissue and contribute to cartilage matrix formation and structural integration in a goat model of autologous chondrocyte implantation

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