The Potentiation of IFN-γ and Induction of Cytotoxic Proteins by Pegylated IL-10 in Human CD8 T Cells
Author:
Affiliation:
1. ARMO BioSciences, Inc., Redwood City, California.
Publisher
Mary Ann Liebert Inc
Subject
Virology,Cell Biology,Immunology
Link
http://www.liebertpub.com/doi/pdf/10.1089/jir.2014.0221
Reference27 articles.
1. IL-10 expression by CT26 colon carcinoma cells inhibits their malignant phenotype and induces a T cell-mediated tumor rejection in the context of a systemic Th2 response
2. Immunoregulation of dendritic cells by IL-10 is mediated through suppression of the PI3K/Akt pathway and of IκB kinase activity
3. IL-10 enhances NK cell proliferation, cytotoxicity and production of IFN-γ when combined with IL-18
4. Interleukin 10 (IL-10) inhibits the release of proinflammatory cytokines from human polymorphonuclear leukocytes. Evidence for an autocrine role of tumor necrosis factor and IL-1 beta in mediating the production of IL-8 triggered by lipopolysaccharide.
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