The BACE1-Specific DNA Aptamer A1 Rescues Amyloid-β Pathology and Behavioral Deficits in a Mouse Model of Alzheimer's Disease-Reference-Cited by-同舟云学术

The BACE1-Specific DNA Aptamer A1 Rescues Amyloid-β Pathology and Behavioral Deficits in a Mouse Model of Alzheimer's Disease

Published:2019-12-01 Issue:6 Volume:29 Page:359-366
ISSN:2159-3337
Container-title:Nucleic Acid Therapeutics
language:en
Short-container-title:Nucleic Acid Therapeutics

Author:

Liang Zhi-Man¹²,Peng Yong-Hua¹,Chen Yue¹,Long Li-Li³,Luo Hong-Jie³,Chen Ya-Jun³,Liang Yan-Ling¹,Tian Ying-Hong⁴,Li Shu-Ji¹,Shi Yu-Sheng⁵,Zhang Xing-Mei¹

Affiliation:

1. Key Laboratory of Mental Health of the Ministry of Education, Guangdong-Hong Kong-Macao Greater Bay Area Center for Brain Science and Brain-Inspired Intelligence, Guangdong Province Key Laboratory of Psychiatric Disorders, Department of Neurobiology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China.

2. Department of Pathology, The Fifth Affiliated Hospital, Southern Medical University, Guangzhou, China.

3. The First Affiliated Hospital, Southern Medical University, Guangzhou, China.

4. Experiment Teaching & Administration Center, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China.

5. Department of Radiation Oncology, Nanfang Hospital, Southern Medical University, Guangzhou, China.

Publisher

Mary Ann Liebert Inc

Subject

Drug Discovery,Genetics,Molecular Biology,Molecular Medicine,Biochemistry

Link

https://www.liebertpub.com/doi/pdf/10.1089/nat.2019.0812

Reference47 articles.

1. Increased Plasma Beta-Secretase 1 May Predict Conversion to Alzheimer’s Disease Dementia in Individuals With Mild Cognitive Impairment

2. β-Secretase Protein and Activity Are Increased in the Neocortex in Alzheimer Disease

3. Increased expression of the amyloid precursor ?-secretase in Alzheimer's disease

4. Amyloid peptide load is correlated with increased -secretase activity in sporadic Alzheimer's disease patients

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