Oxidative Stress-Induced Hypermethylation of KLF5 Promoter Mediated by DNMT3B Impairs Osteogenesis by Diminishing the Interaction with β-Catenin-Reference-Cited by-同舟云学术

Oxidative Stress-Induced Hypermethylation of KLF5 Promoter Mediated by DNMT3B Impairs Osteogenesis by Diminishing the Interaction with β-Catenin

Published:2021-07-01 Issue:1 Volume:35 Page:1-20
ISSN:1523-0864
Container-title:Antioxidants & Redox Signaling
language:en
Short-container-title:Antioxidants & Redox Signaling

Author:

Li Liangping¹²³,Wang Haoming¹²,Chen Xiaoying⁴,Li Xiang¹²,Wang Gangliang¹²,Jie Zhiwei¹²,Zhao Xiangde¹²,Sun Xuewu¹²,Huang Hai¹²,Fan Shunwu¹²,Xie Ziang¹²,Wang Jian¹²⁵

Affiliation:

1. Department of Orthopaedics, Medical College of Zhejiang University, Sir Run Run Shaw Hospital, Hangzhou, People's Republic of China.

2. Key Laboratory of Musculoskeletal System Degeneration and Regeneration Translational Research of Zhejiang Province, Hangzhou, People's Republic of China.

3. Department of Surgery, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, People's Republic of China.

4. Department of Emergency, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, People's Republic of China.

5. Department of Orthopaedics, Tongde Hospital of Zhejiang Province, Hangzhou, People's Republic of China.

Publisher

Mary Ann Liebert Inc

Subject

Cell Biology,Clinical Biochemistry,Molecular Biology,Physiology,Biochemistry,Cell Biology,Clinical Biochemistry,Molecular Biology,Physiology,Biochemistry

Link

https://www.liebertpub.com/doi/pdf/10.1089/ars.2020.8200

Reference74 articles.

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2. Klf4 and Klf5 differentially inhibit mesoderm and endoderm differentiation in embryonic stem cells

3. Oxidative Stress Antagonizes Wnt Signaling in Osteoblast Precursors by Diverting β-Catenin from T Cell Factor- to Forkhead Box O-mediated Transcription

4. WNT signaling in bone homeostasis and disease: from human mutations to treatments

5. Dnmt3a and Dnmt3b Have Overlapping and Distinct Functions in Hematopoietic Stem Cells

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