Constitutively Active G Protein-Coupled Receptor Mutants: Implications on Receptor Function and Drug Action
Author:
Affiliation:
1. Institute of Pharmacology and Toxicology, University of Lausanne, Switzerland
2. Dulbecco Telethon Institute and Department of Chemistry, University of Modena and Reggio Emilia, Italy
3. Istituto Superiore di Sanità, Rome, Italy
Publisher
Mary Ann Liebert Inc
Subject
Drug Discovery,Molecular Medicine
Link
http://www.liebertpub.com/doi/pdf/10.1089/15406580360545125
Reference29 articles.
1. G‐protein‐coupled receptors: molecular mechanisms involved in receptor activation and selectivity of G‐protein recognition
2. Regions of the alpha 1-adrenergic receptor involved in coupling to phosphatidylinositol hydrolysis and enhanced sensitivity of biological function.
3. Constitutive activation of the alpha 1B-adrenergic receptor by all amino acid substitutions at a single site. Evidence for a region which constrains receptor activation.
4. Constitutively active mutants of the alpha 2-adrenergic receptor
5. A mutation-induced activated state of the beta 2-adrenergic receptor. Extending the ternary complex model.
Cited by 16 articles. 订阅此论文施引文献 订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献
1. Domains for activation and inactivation in G protein-coupled receptors – A mutational analysis of constitutive activity of the adenosine A2B receptor;Biochemical Pharmacology;2014-11
2. Constitutive Activities in the Thyrotropin Receptor;Pharmacology & Therapeutics of Constitutively Active Receptors;2014
3. Novel Insights on Thyroid-Stimulating Hormone Receptor Signal Transduction;Endocrine Reviews;2013-05-03
4. Ligand-mimicking Receptor Variant Discloses Binding and Activation Mode of Prolactin-releasing Peptide;Journal of Biological Chemistry;2012-09
5. COMPUTATIONAL MODELING OF CONSTITUTIVELY ACTIVE MUTANTS OF GPCRS: C5A RECEPTOR;METHOD ENZYMOL;2010
1.学者识别学者识别
2.学术分析学术分析
3.人才评估人才评估
"同舟云学术"是以全球学者为主线，采集、加工和组织学术论文而形成的新型学术文献查询和分析系统，可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容，当前同舟云学术共收录了国内外主流学术期刊6万余种，收集的期刊论文及会议论文总量共计约1.5亿篇，并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询！咨询电话：010-8811{复制后删除}0370
www.globalauthorid.com
TOP
Copyright © 2019-2024 北京同舟云网络信息技术有限公司 京公网安备11010802033243号 京ICP备18003416号-3