Assessing the Minimum Number of Data Points Required for Accurate IC50 Determination
Author:
Affiliation:
1. Novartis Institutes for Biomedical Research, Horsham, UK.
Publisher
Mary Ann Liebert Inc
Subject
Drug Discovery,Molecular Medicine
Link
http://www.liebertpub.com/doi/pdf/10.1089/adt.2005.3.525
Reference7 articles.
1. Chapter 27. Application of Combinatorial and Parallel Synthesis to Medicinal Chemistry
2. Life in the fast lane: High-throughput chemistry for lead generation and optimisation
3. Relationship between the inhibition constant (KI) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction
4. Optimizing Higher Throughput Methods to Assess Drug-Drug Interactions for CYP1A2, CYP2C9, CYP2C19, CYP2D6, rCYP2D6, and CYP3A4 In Vitro Using a Single Point IC50
5. Fully automated analysis of activities catalysed by the major human liver cytochrome P450 (CYP) enzymes: assessment of human CYP inhibition potential
Cited by 19 articles. 订阅此论文施引文献 订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献
1. Cell-specific models reveal conformation-specific RAF inhibitor combinations that synergistically inhibit ERK signaling in pancreatic cancer cells;Cell Reports;2024-09
2. The Antidepressant Paroxetine Reduces the Cardiac Sodium Current;International Journal of Molecular Sciences;2023-01-18
3. Activity of (1-benzyl-4-triazolyl)-indole-2-carboxamides against Toxoplasma gondii and Cryptosporidium parvum;International Journal for Parasitology: Drugs and Drug Resistance;2022-08
4. IC50: an unsuitable measure for large-sized prostate cancer spheroids in drug sensitivity evaluation;Bosnian Journal of Basic Medical Sciences;2022-06-09
5. Investigations of AGEs’ inhibitory and nephroprotective potential of ursolic acid towards reduction of diabetic complications;Journal of Natural Medicines;2022-01-15
1.学者识别学者识别
2.学术分析学术分析
3.人才评估人才评估
"同舟云学术"是以全球学者为主线，采集、加工和组织学术论文而形成的新型学术文献查询和分析系统，可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容，当前同舟云学术共收录了国内外主流学术期刊6万余种，收集的期刊论文及会议论文总量共计约1.5亿篇，并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询！咨询电话：010-8811{复制后删除}0370
www.globalauthorid.com
TOP
Copyright © 2019-2024 北京同舟云网络信息技术有限公司 京公网安备11010802033243号 京ICP备18003416号-3