Interleukin 12 Gene Therapy of Cancer by Peritumoral Injection of Transduced Autologous Fibroblasts: Outcome of a Phase I Study

Author:

Kang Won Ki1,Park Chaehwa2,Yoon Hyunah Lee2,Kim Won Seog3,Yoon Sung-Soo3,Lee Mark H.4,Park Keunchil3,Kim Kihyun3,Jeong Hyun Sik3,Kim Jeong-A5,Nam Seok-Jin6,Yang Jung-Hyun6,Son Young-Ik7,Baek Chung-Hwan7,Han Jungho8,Ree Howe J.8,Lee Eil Soo9,Kim Sun Hee10,Kim Dae-Won10,Ahn Yong Chan11,Huh Seung Jae11,Choe Yeon Hyeon12,Lee Je-Ho13,Park Mary H.2,Kong Gyoung-Sun2,Park Eun-Young2,Kang Yoon-Koo14,Bang Yung-Jue15,Paik Nam-Sun16,Lee Soon Nam17,Kim Seon-Hee18,Kim Sunyoung18,Robbins Paul D.19,Tahara Hideaki19,Lotze Michael T.19,Park Chan H.4

Affiliation:

1. Cancer Center, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 135-710, Korea and Division of Hematology and Oncology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 135-710, Korea

2. Cancer Center, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 135-710, Korea

3. Division of Hematology and Oncology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 135-710, Korea.

4. Cancer Center, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 135-710, Korea and Division of Hematology and Oncology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 135-710, Korea.

5. Division of Hematology and Oncology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 135-710, Korea and Department of Medicine, St. Vincent's Hospital, Catholic University, Suwon 442-723, Korea

6. Department of General Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 135-710, Korea

7. Department of Otorhinolaryngology/Head and Neck Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 135-710, Korea

8. Department of Diagnostic Pathology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 135-710, Korea

9. Department of Dermatology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 135-710, Korea

10. Department of Clinical Pathology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 135-710, Korea

11. Department of Radiation Oncology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 135-710, Korea

12. Department of Radiology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 135-710, Korea

13. Department of Obstetrics and Gynecology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 135-710, Korea

14. Department of Internal Medicine, Asan Medical Center, Ulsan University, Seoul 138-736, Korea

15. Department of Internal Medicine, Seoul National University Hospital, Seoul 110-744, Korea

16. Department of General Surgery, Korea Cancer Center, Seoul, 139-706, Korea

17. Department of Internal Medicine, Ewha Womans University Hospital, Seoul 110-126, Korea

18. Institute for Molecular Biology and Genetics, Seoul National University, Seoul 151-742, Korea

19. University of Pittsburgh School of Medicine, Pittsburgh, PA 15261

Publisher

Mary Ann Liebert Inc

Subject

Genetics,Molecular Biology,Molecular Medicine

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