Adenovirus-Mediated Factor VIII Gene Expression Results in Attenuated Anti-Factor VIII-Specific Immunity in Hemophilia A Mice Compared with Factor VIII Protein Infusion
Author:
Affiliation:
1. DNA Viral Vectors Unit, Genetic Therapy, Inc., A Novartis Company, Gaithersburg, MD 20878.
Publisher
Mary Ann Liebert Inc
Subject
Genetics,Molecular Biology,Molecular Medicine
Link
http://www.liebertpub.com/doi/pdf/10.1089/10430340152528147
Reference56 articles.
1. Production and Characterization of Improved Adenovirus Vectors with the E1, E2b, and E3 Genes Deleted
2. Targeted disruption of the mouse factor VIII gene produces a model of haemophilia A
3. German recommendations for immune tolerance therapy in type A haemophiliacs with antibodies
4. In Vivo Dose Threshold Effect of Adenovirus-Mediated Factor VIII Gene Therapy in Hemophiliac Mice
5. The Canine Factor VIII cDNA and 5’ Flanking Sequence
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3. The treatment of hemophilia A: from protein replacement to AAV-mediated gene therapy;Biotechnology Letters;2008-11-02
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5. Absence of a desmopressin response after therapeutic expression of factor VIII in hemophilia A dogs with liver-directed neonatal gene therapy;Proceedings of the National Academy of Sciences;2005-04-18
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