Multi-Log Cytotoxicity of Carbocyclic 2′-Deoxyguanosine in HSV-TK-Expressing Human Tumor Cells-Reference-Cited by-同舟云学术

Multi-Log Cytotoxicity of Carbocyclic 2′-Deoxyguanosine in HSV-TK-Expressing Human Tumor Cells

Published:2002-03 Issue:4 Volume:13 Page:543-551
ISSN:1043-0342
Container-title:Human Gene Therapy
language:en
Short-container-title:Human Gene Therapy

Author:

Shewach Donna S.¹,Murphy Patrick J.¹,Robinson Blaine W.¹,Vuletich Jennifer¹,Boucher Paul D.¹,Blobaum Anna L.¹,Zerbe Laura¹,Secrist John A.²,Parker William B.²

Affiliation:

1. Department of Pharmacology, University of Michigan Medical School, Ann Arbor, MI 48109

2. Southern Research Institute, Birmingham, AL 35205

Publisher

Mary Ann Liebert Inc

Subject

Genetics,Molecular Biology,Molecular Medicine

Link

http://www.liebertpub.com/doi/pdf/10.1089/10430340252809838

Reference52 articles.

1. Synergistic Anticancer Effects of Ganciclovir/Thymidine Kinase and 5-Fluorocytosine/Cytosine Deaminase Gene Therapies

2. Differential mechanism of cytostatic effect of (E)-5-(2-bromovinyl)-2'-deoxyuridine, 9-(1,3-dihydroxy-2-propoxymethyl)guanine, and other antiherpetic drugs on tumor cells transfected by the thymidine kinase gene of herpes simplex virus type 1 or type 2.

3. Metabolism in Human Cells of the d and l Enantiomers of the Carbocyclic Analog of 2′-Deoxyguanosine: Substrate Activity with Deoxycytidine Kinase, Mitochondrial Deoxyguanosine Kinase, and 5′-Nucleotidase

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1. Alteration of the carbohydrate for deoxyguanosine analogs markedly changes DNA replication fidelity, cell cycle progression and cytotoxicity;Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis;2010-02