Activation of the Interleukin-18 Signaling Pathway via Direct Receptor Dimerization in the Absence of Interleukin-18-Reference-Cited by-同舟云学术

Activation of the Interleukin-18 Signaling Pathway via Direct Receptor Dimerization in the Absence of Interleukin-18

Published:2024-01-01 Issue:1 Volume:44 Page:37-42
ISSN:1079-9907
Container-title:Journal of Interferon & Cytokine Research
language:en
Short-container-title:Journal of Interferon & Cytokine Research

Author:

Mortazavi Yasaman¹,Herrera Robert¹,Masureel Matthieu²,Maculins Timurs¹,Lehoux Isabelle³,Sockolosky Jonathan⁴,West Nathan⁵,Bulutoglu Beyza⁶,Zhao Yue¹^ORCID

Affiliation:

1. Department of Biochemical and Cellular Pharmacology, Genentech, South San Francisco, California, USA.

2. Department of Structural Biology, Genentech, South San Francisco, California, USA.

3. Department of BioMolecular Resources, Genentech, South San Francisco, California, USA.

4. Department of Antibody Engineering, Genentech, South San Francisco, California, USA.

5. Department of Cancer Immunology, Genentech, South San Francisco, California, USA.

6. Department of Protein Chemistry, Genentech, South San Francisco, California, USA.

Publisher

Mary Ann Liebert Inc

Subject

Virology,Cell Biology,Immunology

Link

https://www.liebertpub.com/doi/pdf/10.1089/jir.2023.0129

Reference12 articles.

1. Inflammasome signaling and regulation of interleukin-1 family cytokines

2. Synthetic cytokine receptors transmit biological signals using artificial ligands

3. Generation and engineering of potent single domain antibody-based bispecific IL-18 mimetics resistant to IL-18BP decoy receptor inhibition

4. Tuning Cytokine Receptor Signaling by Re-orienting Dimer Geometry with Surrogate Ligands

5. Signal Transduction Using an Artificial Receptor System that Undergoes Dimerization Upon Addition of a Bivalent Leucine-Zipper Ligand