Disposition and Pharmacokinetics of a GalNAc3-Conjugated Antisense Oligonucleotide Targeting Human Lipoprotein (a) in Monkeys-Reference-Cited by-同舟云学术

Disposition and Pharmacokinetics of a GalNAc3-Conjugated Antisense Oligonucleotide Targeting Human Lipoprotein (a) in Monkeys

Published:2016-12 Issue:6 Volume:26 Page:372-380
ISSN:2159-3337
Container-title:Nucleic Acid Therapeutics
language:en
Short-container-title:Nucleic Acid Therapeutics

Author:

Yu Rosie Z.¹,Gunawan Rudy¹,Post Noah¹,Zanardi Thomas¹,Hall Shannon¹,Burkey Jennifer¹,Kim Tae-Won¹,Graham Mark J.¹,Prakash Thazha P.¹,Seth Punit P.¹,Swayze Eric E.¹,Geary Richard S.¹,Henry Scott P.¹,Wang Yanfeng¹

Affiliation:

1. Ionis Pharmaceuticals, Inc., Carlsbad, California.

Publisher

Mary Ann Liebert Inc

Subject

Drug Discovery,Genetics,Molecular Biology,Molecular Medicine,Biochemistry

Link

http://www.liebertpub.com/doi/pdf/10.1089/nat.2016.0623

Reference23 articles.

1. Effect of dose and plasma concentration on liver uptake and pharmacologic activity of a 2′-methoxyethyl modified chimeric antisense oligonucleotide targeting PTEN

2. Potential therapeutic application of antisense oligonucleotides in the treatment of ocular diseases

3. 2′-Carbohydrate modifications in antisense oligonucleotide therapy: importance of conformation, configuration and conjugation

4. Characterization of a Potent and Specific Class of Antisense Oligonucleotide Inhibitor of Human Protein Kinase C-α Expression

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