Safety in Nonhuman Primates of Ocular AAV2-RPE65, a Candidate Treatment for Blindness in Leber Congenital Amaurosis-Reference-Cited by-同舟云学术

Safety in Nonhuman Primates of Ocular AAV2-RPE65, a Candidate Treatment for Blindness in Leber Congenital Amaurosis

Published:2006-08 Issue:8 Volume:17 Page:845-858
ISSN:1043-0342
Container-title:Human Gene Therapy
language:en
Short-container-title:Human Gene Therapy

Author:

Jacobson Samuel G.¹,Boye Sanford L.²,Aleman Tomas S.¹,Conlon Thomas J.³,Zeiss Caroline J.⁴,Roman Alejandro J.¹,Cideciyan Artur V.¹,Schwartz Sharon B.¹,Komaromy Andras M.⁵,Doobrajh Michelle¹,Cheung Andy Y.¹,Sumaroka Alexander¹,Pearce-Kelling Susan E.⁶,Aguirre Gustavo D.⁵,Kaushal Shalesh²,Maguire Albert M.¹,Flotte Terence R.³,Hauswirth William W.²³

Affiliation:

1. Department of Ophthalmology, Scheie Eye Institute, University of Pennsylvania, Philadelphia, PA 19104.

2. Department of Ophthalmology, University of Florida, Gainesville, FL 32610.

3. Powell Gene Therapy Center, Genetics Institute, and Departments of Pediatrics, Pathology, and Pharmaceutics, University of Florida, Gainesville, FL 32610.

4. Section of Comparative Medicine, Yale University School of Medicine, New Haven, CT 06520.

5. Section of Medical Genetics, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104.

6. James A. Baker Institute for Animal Health, Cornell University, Ithaca, NY 14853.

Publisher

Mary Ann Liebert Inc

Subject

Genetics,Molecular Biology,Molecular Medicine

Link

http://www.liebertpub.com/doi/pdf/10.1089/hum.2006.17.845

Reference40 articles.

1. Gene therapy restores vision in a canine model of childhood blindness

2. Long-Term Restoration of Rod and Cone Vision by Single Dose rAAV-Mediated Gene Transfer to the Retina in a Canine Model of Childhood Blindness