Development and Application of a Liquid Chromatography-Mass Spectrometry Method for Residual Iodixanol Quantification in AAV-Based Gene Therapy Product Development-Reference-Cited by-同舟云学术

Development and Application of a Liquid Chromatography-Mass Spectrometry Method for Residual Iodixanol Quantification in AAV-Based Gene Therapy Product Development

Published:2022-01-01 Issue:1-2 Volume:33 Page:103-108
ISSN:1043-0342
Container-title:Human Gene Therapy
language:en
Short-container-title:Human Gene Therapy

Author:

Pu Yi¹^ORCID,Katz Russell²,Chen Yunqiu¹,Kostrubsky Vic³,Clarner Pete⁴,Lo Shih-Ching⁵,Sosic Zoran¹,Yeung Bernice¹

Affiliation:

1. Analytical Development, Cambridge, Massachusetts, USA.

2. Gene Therapy-Process Development, Cambridge, Massachusetts, USA.

3. Preclinical Safety, Cambridge, Massachusetts, USA.

4. Gene Therapy Accelerator Unit, Cambridge, Massachusetts, USA.

5. Research, Biogen, Inc., Cambridge, Massachusetts, USA.

Publisher

Mary Ann Liebert Inc

Subject

Genetics,Molecular Biology,Molecular Medicine

Link

https://www.liebertpub.com/doi/pdf/10.1089/hum.2021.136

Reference20 articles.

1. Direct Liquid Chromatography/Mass Spectrometry Analysis for Complete Characterization of Recombinant Adeno-Associated Virus Capsid Proteins

2. Thermal Stability as a Determinant of AAV Serotype Identity

3. Engineering adeno-associated virus vectors for gene therapy

4. Effect of heart ischemia and administration route on biodistribution and transduction efficiency of AAV9 vectors

5. Comparative Analysis of Cesium Chloride- and Iodixanol-Based Purification of Recombinant Adeno-Associated Viral Vectors for Preclinical Applications

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1. Advances and opportunities in process analytical technologies for viral vector manufacturing;Biotechnology Advances;2024-09

2. Comprehensive Comparison of AAV Purification Methods: Iodixanol Gradient Centrifugation vs. Immuno-Affinity Chromatography;Advances in Cell and Gene Therapy;2023-12-11

3. The downstream bioprocess toolbox for therapeutic viral vectors;Journal of Chromatography A;2023-10

4. Mass spectrometry in gene therapy: Challenges and opportunities for AAV analysis;Drug Discovery Today;2023-01