An Automated High Throughput Liquid Chromatography–Mass Spectrometry Process to Assess the Metabolic Stability of Drug Candidates-Reference-Cited by-同舟云学术

An Automated High Throughput Liquid Chromatography–Mass Spectrometry Process to Assess the Metabolic Stability of Drug Candidates

Published:2007-04 Issue:2 Volume:5 Page:247-264
ISSN:1540-658X
Container-title:ASSAY and Drug Development Technologies
language:en
Short-container-title:ASSAY and Drug Development Technologies

Author:

Drexler Dieter M.¹,Belcastro James V.²,Dickinson Kenneth E.²,Edinger Kurt J.²,Hnatyshyn Serhiy Y.³,Josephs Jonathan L.⁴,Langish Robert A.⁵,McNaney Colleen A.¹,Santone Kenneth S.⁶,Shipkova Petia A.⁵,Tymiak Adrienne A.³,Zvyaga Tatyana A.²,Sanders Mark³

Affiliation:

1. Discovery Analytical Sciences, Pharmaceutical Research Institute, Bristol-Myers Squibb Company, Wallingford, CT.

2. Molecular Biosciences—Lead Discovery and Profiling, Applied Biotechnologies, Pharmaceutical Research Institute, Bristol-Myers Squibb Company, Wallingford, CT.

3. Discovery Analytical Sciences, Pharmaceutical Candidate Optimization, Pharmaceutical Research Institute, Bristol-Myers Squibb Company, Princeton, NJ.

4. Biotransformation, Pharmaceutical Candidate Optimization, Pharmaceutical Research Institute, Bristol-Myers Squibb Company, Pennington, NJ.

5. Discovery Analytical Sciences, Pharmaceutical Candidate Optimization, Pharmaceutical Research Institute, Bristol-Myers Squibb Company, Pennington, NJ.

6. Metabolism and Pharmacokinetics—Discovery Support, Pharmaceutical Candidate Optimization, Pharmaceutical Research Institute, Bristol-Myers Squibb Company, Wallingford, CT.

Publisher

Mary Ann Liebert Inc

Subject

Drug Discovery,Molecular Medicine

Link

http://www.liebertpub.com/doi/pdf/10.1089/adt.2006.038

Reference24 articles.

1. Improving the hit-to-lead process: data-driven assessment of drug-like and lead-like screening hits

2. High throughput physicochemical profiling for drug discovery

3. In vitro preclinical lead optimisation technologies (PLOTs) in pharmaceutical development

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