Coexpression of Tyrosine Hydroxylase, GTP Cyclohydrolase I, Aromatic Amino Acid Decarboxylase, and Vesicular Monoamine Transporter 2 from a Helper Virus-Free Herpes Simplex Virus Type 1 Vector Supports High-Level, Long-Term Biochemical and Behavioral Correction of a Rat Model of Parkinson's Disease-Reference-Cited by-同舟云学术

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Coexpression of Tyrosine Hydroxylase, GTP Cyclohydrolase I, Aromatic Amino Acid Decarboxylase, and Vesicular Monoamine Transporter 2 from a Helper Virus-Free Herpes Simplex Virus Type 1 Vector Supports High-Level, Long-Term Biochemical and Behavioral Correction of a Rat Model of Parkinson's Disease

Published:2004-12 Issue:12 Volume:15 Page:1177-1196
ISSN:1043-0342
Container-title:Human Gene Therapy
language:en
Short-container-title:Human Gene Therapy

Author:

Sun Mei¹,Kong Lingxin¹,Wang Xiaodan¹,Holmes Courtney²,Gao Qingsheng¹,Zhang Guo-Rong¹,Pfeilschifter Josef³,Goldstein David S.²,Geller Alfred I.¹

Affiliation:

1. Department of Neurology, West Roxbury VA Hospital/Harvard Medical School, West Roxbury, MA 02132.

2. Clinical Neurocardiology Section, National Institute of Neurological Disease and Stroke, Bethesda, MD 20892.

3. Pharmazentrum Frankfurt, University Hospital, 60590 Frankfurt, Germany.

Publisher

Mary Ann Liebert Inc

Subject

Genetics,Molecular Biology,Molecular Medicine

Link

http://www.liebertpub.com/doi/pdf/10.1089/hum.2004.15.1177

Reference64 articles.

1. Multicistronic Lentiviral Vector-Mediated Striatal Gene Transfer of Aromatic l-Amino Acid Decarboxylase, Tyrosine Hydroxylase, and GTP Cyclohydrolase I Induces Sustained Transgene Expression, Dopamine Production, and Functional Improvement in a Rat Model of Parkinson's Disease.

2. Functional integration of neural grafts in Parkinson's disease

3. Double Transduction with GTP Cyclohydrolase I and Tyrosine Hydroxylase Is Necessary for Spontaneous Synthesis ofl-DOPA by Primary Fibroblasts

4. Towards a neuroprotective gene therapy for Parkinson’s disease: use of adenovirus, AAV and lentivirus vectors for gene transfer of GDNF to the nigrostriatal system in the rat Parkinson model11Published on the World Wide Web on 10 October 2000.

5. Immune responses to replication-defective HSV-1 type vectors within the CNS: implications for gene therapy

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1. Potential Therapeutic Approach using Aromatic l-amino Acid Decarboxylase and Glial-derived Neurotrophic Factor Therapy Targeting Putamen in Parkinson's Disease;Current Gene Therapy;2024-08

2. An HSV-1-H129 amplicon tracer system for rapid and efficient monosynaptic anterograde neural circuit tracing;Nature Communications;2022-12-10

3. Connected neurons in multiple neocortical areas, comprising parallel circuits, encode essential information for visual shape learning;Journal of Chemical Neuroanatomy;2021-12

4. Helper virus-free gutless adenovirus (HF-GLAd): a new platform for gene therapy;BMB Reports;2020-11-30

5. Delivery of different genes into pre- and post-synaptic neocortical interneurons connected by GABAergic synapses;PLOS ONE;2019-05-24

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