Neuroprotective Gene Therapy for Huntington's Disease, Using Polymer-Encapsulated Cells Engineered to Secrete Human Ciliary Neurotrophic Factor: Results of a Phase I Study-Reference-Cited by-同舟云学术

Neuroprotective Gene Therapy for Huntington's Disease, Using Polymer-Encapsulated Cells Engineered to Secrete Human Ciliary Neurotrophic Factor: Results of a Phase I Study

Published:2004-10 Issue:10 Volume:15 Page:968-975
ISSN:1043-0342
Container-title:Human Gene Therapy
language:en
Short-container-title:Human Gene Therapy

Author:

Bloch J.¹²,Bachoud-Lévi A.C.³⁴,Déglon N.¹,Lefaucheur J.P.³⁵,Winkel L.¹,Palfi S.⁶⁷,Nguyen J.P.³⁶,Bourdet C.⁸,Remy P.³⁴⁷,Brugières P.³⁹,Boisse M. F.⁴,Baudic S.³,Cesaro P.⁴³,Hantraye P.⁷,Aebischer P.¹,Peschanski M.³

Affiliation:

1. Swiss Federal Institute of Technology Lausanne, Ecole Polytechnique Fédérale de Lausanne, 1015 Lausanne, Switzerland.

2. Service de Neurochirurgie, Centre Hospitalier Universitaire Vaudois, 1011 Lausanne, Switzerland.

3. INSERM/UPVM U 421, Faculté de Médecine, 94010 Créteil, France.

4. Service de Neurologie, Centre Hospitalier Universitaire Henri-Mondor AP/HP, 94010 Créteil, France.

5. Service d'Explorations Fonctionnelles, Centre Hospitalier Universitaire Henri-Mondor AP/HP, 94010 Créteil, France.

6. Service de Neurochirurgie, Centre Hospitalier Universitaire Henri-Mondor AP/HP, 94010 Créteil, France.

7. CEA/CNRS URA 2210, Service Hospitalier Frédéric Joliot, 91401 Orsay, France.

8. Service de Psychiatrie, Hôpital Albert Chenevier AP/HP, 94010 Créteil, France.

9. Service de Neuroradiologie, Centre Hospitalier Universitaire Henri-Mondor AP/HP, 94010 Créteil, France.

Publisher

Mary Ann Liebert Inc

Subject

Genetics,Molecular Biology,Molecular Medicine

Link

http://www.liebertpub.com/doi/pdf/10.1089/hum.2004.15.968

Reference35 articles.

1. Intrathecal delivery of CNTF using encapsulated genetically modifiedxenogeneic cells in amyotrophic lateral sclerosis patients

2. Gene Therapy for Amyotrophic Lateral Sclerosis (ALS) Using a Polymer Encapsulated Xenogenic Cell Line Engineered to Secrete hCNTF. Lausanne University Medical School, Lausanne, Switzerland

3. Ciliary neurotrophic factor protects striatal output neurons in an animal model of Huntington disease.

4. Safety and Tolerability Assessment of Intrastriatal Neural Allografts in Five Patients with Huntington's Disease

5. Motor and cognitive improvements in patients with Huntington's disease after neural transplantation

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