Enzyme-Linked Bridging Assay Method for the Quantification of Oligonucleotide-Based Drugs in Biological Matrices
Author:
Affiliation:
1. Department of Pharmacology and Toxicology, Beijing Institute of Radiation Medicine, Beijing, People's Republic of China.
2. Department of General Surgery, General Hospital of PLA, Beijing, People's Republic of China.
Publisher
Mary Ann Liebert Inc
Subject
Drug Discovery,Genetics,Molecular Biology,Molecular Medicine,Biochemistry
Link
http://www.liebertpub.com/doi/pdf/10.1089/nat.2011.0319
Reference12 articles.
1. A competitive enzyme hybridization assay for plasma determination of phosphodiester and phosphorothioate antisense oligonucleotides
2. Quantification of Oligodeoxynucleotides in Human Plasma with a Novel Hybridization Assay Offers Greatly Enhanced Sensitivity over Capillary Gel Electrophoresis
3. Identification and quantification of GC-rich oligodeoxynucleotides in tissue extracts by capillary gel electrophoresis
4. On-column electroextraction and separation of antisense oligonucleotides in human plasma by capillary gel electrophoresis
5. Effect of biological matrix and sample preparation on qPCR quantitation of siRNA drugs in animal tissues
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1. Sensitive and specific quantification of antisense oligonucleotides using probe alteration-linked self-assembly reaction technology;BioTechniques;2023-07
2. Development and validation of a high performance liquid chromatography method for oligodeoxynucleotides determination in a novel coagel-based formulation;Analytical Chemistry Research;2015-06
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