Phosphodiester Oligonucleotides Inhibit Mitosis and Trigger Apoptosis by a Non-Antisense, p53-Mediated Mechanism
Author:
Affiliation:
1. Department of Experimental Pathology and Oncology, University of Florence, 50134-Florence, Italy.
Publisher
Mary Ann Liebert Inc
Subject
Pharmacology,Genetics
Link
http://www.liebertpub.com/doi/pdf/10.1089/108729002753670238
Reference49 articles.
1. p53 binds single-stranded DNA ends and catalyzes DNA renaturation and strand transfer.
2. p53 binds single-stranded DNA ends through the C-terminal domain and internal DNA segments via the middle domain
3. Synthetic unmethylated cytosine-phosphate-guanosine oligodeoxynucleotides are potent stimulators of antileukemia responses in naive and bone marrow transplant recipients
4. A good antisense molecule is hard to find
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