Evaluation of Pharmacokinetics and Metabolism of Phosphorothioate Antisense Oligonucleotide G3139 in Rat by Capillary Electrophoresis with Laser-Induced Fluorescence
Author:
Affiliation:
1. College of Pharmacy, Graduate School of Pharmaceutical Sciences, Ewha Womans University, Seoul, Korea.
Publisher
Mary Ann Liebert Inc
Subject
Drug Discovery,Genetics,Molecular Biology,Molecular Medicine,Biochemistry
Link
https://www.liebertpub.com/doi/pdf/10.1089/nat.2020.0922
Reference18 articles.
1. Progress in Antisense Technology
2. Delivery of Antisense Oligonucleotides to the Cornea
3. Antisense Oligonucleotide: Basic Concepts and Therapeutic Application in Inflammatory Bowel Disease
4. Quantification of oligonucleotides by LC–MS/MS: the challenges of quantifying a phosphorothioate oligonucleotide and multiple metabolites
5. A Specific Picomolar Hybridization-Based ELISA Assay for the Determination of Phosphorothioate Oligonucleotides in Plasma and Cellular Matrices
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1. Efficient delivery of the Bcl-2 antisense oligonucleotide G3139 via nucleus-targeted aCD33-NKSN nanoparticles;International Journal of Pharmaceutics;2022-09
2. Analysis of therapeutic nucleic acids by capillary electrophoresis;Journal of Pharmaceutical and Biomedical Analysis;2022-09
3. Applications of capillary electrophoresis in the fields of environmental, pharmaceutical, clinical, and food analysis (2019–2021);Journal of Separation Science;2022-04-15
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