Hsc70 Facilitates Mannose-6-Phosphate Receptor-Mediated Intracellular Trafficking and Enhances Endosomal Release of Phosphorothioate-Modified Antisense Oligonucleotides-Reference-Cited by-同舟云学术

Hsc70 Facilitates Mannose-6-Phosphate Receptor-Mediated Intracellular Trafficking and Enhances Endosomal Release of Phosphorothioate-Modified Antisense Oligonucleotides

Published:2021-08-01 Issue:4 Volume:31 Page:284-297
ISSN:2159-3337
Container-title:Nucleic Acid Therapeutics
language:en
Short-container-title:Nucleic Acid Therapeutics

Author:

Liang Xue-Hai¹,Nichols Joshua G.¹,Hsu Chih-Wei¹,Crooke Stanley T.¹

Affiliation:

1. Department of Core Antisense Research, Ionis Pharmaceuticals, Inc., Carlsbad, California, USA.

Publisher

Mary Ann Liebert Inc

Subject

Drug Discovery,Genetics,Molecular Biology,Molecular Medicine,Biochemistry

Link

https://www.liebertpub.com/doi/pdf/10.1089/nat.2020.0920

Reference43 articles.

1. RNA-Targeted Therapeutics

2. Cellular uptake and trafficking of antisense oligonucleotides

3. RNase H1-Dependent Antisense Oligonucleotides Are Robustly Active in Directing RNA Cleavage in Both the Cytoplasm and the Nucleus

4. Receptors, endocytosis, and trafficking: the biological basis of targeted delivery of antisense and siRNA oligonucleotides

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