Interspecies Scaling of Human Clearance and Plasma Trough Exposure for Antisense Oligonucleotides: A Retrospective Analysis of GalNAc3-Conjugated and Unconjugated-Antisense Oligonucleotides-Reference-Cited by-同舟云学术

Interspecies Scaling of Human Clearance and Plasma Trough Exposure for Antisense Oligonucleotides: A Retrospective Analysis of GalNAc3-Conjugated and Unconjugated-Antisense Oligonucleotides

Published:2021-08-01 Issue:4 Volume:31 Page:298-308
ISSN:2159-3337
Container-title:Nucleic Acid Therapeutics
language:en
Short-container-title:Nucleic Acid Therapeutics

Author:

Nanavati Charvi¹,McMullen Gina¹,Yu Rosie¹,Geary Richard S.¹,Henry Scott P.¹,Wang Yanfeng¹

Affiliation:

1. Ionis Pharmaceuticals, Inc., Carlsbad, California, USA.

Publisher

Mary Ann Liebert Inc

Subject

Drug Discovery,Genetics,Molecular Biology,Molecular Medicine,Biochemistry

Link

https://www.liebertpub.com/doi/pdf/10.1089/nat.2020.0911

Reference18 articles.

1. RNA-Targeted Therapeutics

2. Antisense oligonucleotide pharmacokinetics and metabolism

3. Pharmacokinetics, biodistribution and cell uptake of antisense oligonucleotides

4. Pharmacokinetics and Clinical Pharmacology Considerations of GalNAc3-Conjugated Antisense Oligonucleotides

5. Clinical pharmacokinetics of second generation antisense oligonucleotides

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