A Pilot Study Measuring the Distribution and Permeability of a Vaginal HIV Microbicide Gel Vehicle Using Magnetic Resonance Imaging, Single Photon Emission Computed Tomography/Computed Tomography, and a Radiolabeled Small Molecule-Reference-Cited by-同舟云学术

A Pilot Study Measuring the Distribution and Permeability of a Vaginal HIV Microbicide Gel Vehicle Using Magnetic Resonance Imaging, Single Photon Emission Computed Tomography/Computed Tomography, and a Radiolabeled Small Molecule

Published:2015-11 Issue:11 Volume:31 Page:1109-1115
ISSN:0889-2229
Container-title:AIDS Research and Human Retroviruses
language:en
Short-container-title:AIDS Research and Human Retroviruses

Author:

Fuchs Edward J.¹,Schwartz Jill L.²,Friend David R.²,Coleman Jenell S.³,Hendrix Craig W.¹

Affiliation:

1. The Division of Clinical Pharmacology, Department of Medicine, Johns Hopkins School of Medicine, Baltimore, Maryland.

2. CONRAD, Eastern Virginia Medical School (EVMS), Arlington, Virginia.

3. The Division of Gynecologic Specialties, Department of Gynecology and Obstetrics, Johns Hopkins School of Medicine, Baltimore, Maryland.

Publisher

Mary Ann Liebert Inc

Subject

Infectious Diseases,Virology,Immunology

Link

http://www.liebertpub.com/doi/pdf/10.1089/aid.2015.0054

Reference20 articles.

1. Effectiveness of COL-1492, a nonoxynol-9 vaginal gel, on HIV-1 transmission in female sex workers: a randomised controlled trial

2. A Dosing Study of Nonoxynol-9 and Genital Irritation

3. Distribution of a spermicide containing Nonoxynol-9 in the vaginal canal and the upper female reproductive tract

4. Distribution of topical medication in the human vagina as imaged by magnetic resonance imaging

5. Use of MRI to determine the in vivo position of a silicone vaginal barrier contraceptive device☆

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2. Hormonal Contraceptives Differentially Suppress TFV and TAF Inhibition of HIV Infection and TFV-DP in Blood and Genital Tract CD4+ T cells;Scientific Reports;2017-12

3. Feasibility of radiolabeled small molecule permeability as a quantitative measure of microbicide candidate toxicity;Contraception;2016-04

4. Tools in Clinical Pharmacology: Imaging Techniques;Clinical Pharmacology: Current Topics and Case Studies;2016