Sequencing of theFrancisella tularensisStrain Schu 4 Genome Reveals the Shikimate and Purine Metabolic Pathways, Targets for the Construction of a Rationally Attenuated Auxotrophic Vaccine

Author:

Karlsson Jan1,Prior Richard G.2,Williams Kerstin3,Lindler Luther4,Brown Katherine A.5,Chatwell Nicola2,Hjalmarsson Karin1,Loman Nick6,Mack Kerri A.2,Pallen Mark7,Popek Michael4,Sandström Gunnar8,Sjöstedt Anders9,Svensson Thomas1,Tamas Ivica10,Andersson Siv G. E.10,Wren Brendan W.3,Oyston Petra C. F.2,Titball Richard W.2

Affiliation:

1. National Defence Research Establishment, Umeå, Sweden

2. Defence Evaluation and Research Agency, CBD Porton Down, Salisbury, Wilts, United Kingdom

3. Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom

4. Department of Bacterial Diseases, Walter Reed Army Institute of Research, Washington, D.C.

5. Department of Biochemistry, Imperial College of Science Technology and Medicine, London, United Kingdom

6. Department of Medical Microbiology, St. Bartholomews and the Royal London School of Medicine and Dentistry, London, United Kingdom

7. Department of Microbiology and Immunobiology, The Queen's University Belfast, Belfast, Ireland

8. National Defence Research Establishment, Umeå, Sweden and Department of Clinical Microbiology, Infectious Diseases, Umeå University, Umeå, Sweden

9. National Defence Research Establishment, Umeå, Sweden and Department of Clinical Microbiology, Clinical Bacteriology, Umeå University, Umeå, Sweden

10. Department of Molecular Evolution, University of Uppsala, Uppsala, Sweden

Publisher

Mary Ann Liebert Inc

Subject

Molecular Biology,Applied Microbiology and Biotechnology

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