Defined Solution Corrects Phenotypic Response and Improves Detection Accuracy of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes to the 28 Comprehensive In Vitro Proarrhythmia Assay Standards
Author:
Affiliation:
1. Merck and Co., Inc., Safety Assessment and Laboratory Animal Resources, Merck Research Laboratory, West Point, Pennsylvania, USA.
Publisher
Mary Ann Liebert Inc
Subject
Health, Toxicology and Mutagenesis,Medical Laboratory Technology,Toxicology
Link
https://www.liebertpub.com/doi/pdf/10.1089/aivt.2020.0013
Reference30 articles.
1. Comprehensive Translational Assessment of Human-Induced Pluripotent Stem Cell Derived Cardiomyocytes for Evaluating Drug-Induced Arrhythmias
2. Estimating the Risk of Drug-Induced Proarrhythmia Using Human Induced Pluripotent Stem Cell–Derived Cardiomyocytes
3. Refining the Human iPSC-Cardiomyocyte Arrhythmic Risk Assessment Model
4. Cardiac drug-drug interaction between HCV-NS5B pronucleotide inhibitors and amiodarone is determined by their specific diastereochemistry
5. High Throughput Measurement of Ca++Dynamics in Human Stem Cell-Derived Cardiomyocytes by Kinetic Image Cytometery: A Cardiac Risk Assessment Characterization Using a Large Panel of Cardioactive and Inactive Compounds
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