Efficient C-to-G Base Editing with Improved Target Compatibility Using Engineered Deaminase

Efficient C-to-G Base Editing with Improved Target Compatibility Using Engineered Deaminase–nCas9 Fusions

Published:2022-06-01 Issue:3 Volume:5 Page:389-396
ISSN:2573-1599
Container-title:The CRISPR Journal
language:en
Short-container-title:The CRISPR Journal

Author:

Chen Siyu¹,Liu Zhiquan¹,Lai Liangxue¹²³⁴,Li Zhanjun¹

Affiliation:

1. Key Laboratory of Zoonosis Research, Ministry of Education, College of Animal Science, Jilin University, Changchun 130062, P.R. China.

2. CAS Key Laboratory of Regenerative Biology, Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, 510530, P.R. China.

3. Guangzhou Regenerative Medicine and Health Guang Dong Laboratory (GRMH-GDL), Guangzhou 510005, P.R. China.

4. Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing 100101, P.R. China.

Publisher

Mary Ann Liebert Inc

Subject

Genetics,Biotechnology

Link

https://www.liebertpub.com/doi/pdf/10.1089/crispr.2021.0124

Reference25 articles.

1. Base editing: precision chemistry on the genome and transcriptome of living cells

2. Genome editing with CRISPR–Cas nucleases, base editors, transposases and prime editors

3. Programmable editing of a target base in genomic DNA without double-stranded DNA cleavage