Particle-Mediated Cytokine Gene Therapy Leads to Antitumor and Antimetastatic Effects in Mouse Carcinoma Models
Author:
Affiliation:
1. Clinic for Visceral, Thoracic, Vascular and Transplant Surgery, University of Leipzig, Leipzig, Germany.
2. Institute of Virology, University of Leipzig, Leipzig, Germany.
3. Institute of Pathology, University of Leipzig, Leipzig, Germany.
Publisher
Mary Ann Liebert Inc
Subject
Cancer Research,Pharmacology,Radiology Nuclear Medicine and imaging,Oncology,General Medicine,Cancer Research,Pharmacology,Radiology Nuclear Medicine and imaging,Oncology,General Medicine
Link
http://www.liebertpub.com/doi/pdf/10.1089/cbr.2006.21.333
Reference22 articles.
1. Antitumor Effects on Mouse Melanoma Elicited by Local Secretion of Interleukin-12 and Their Enhancement by Treatment with Interleukin-18
2. Combined IL-12 and GM-CSF gene therapy for murine hepatocellular carcinoma
3. Intratumoral coinjection of adenoviral vectors expressing IL-2 and IL-12 results in enhanced frequency of regression of injected and untreated distal tumors
4. IL-12- and IL-2-induced tumor regression in a new murine model of oral squamous-cell carcinoma is promoted by expression of the CD80 co-stimulatory molecule and interferon-?
5. Application of interleukin-2–secreting syngeneic/allogeneic fibroblasts in the treatment of primary and metastatic brain tumors
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