Target Gene Abundance Contributes to the Efficiency of siRNA-Mediated Gene Silencing-Reference-Cited by-同舟云学术

Target Gene Abundance Contributes to the Efficiency of siRNA-Mediated Gene Silencing

Published:2014-06 Issue:3 Volume:24 Page:192-198
ISSN:2159-3337
Container-title:Nucleic Acid Therapeutics
language:en
Short-container-title:Nucleic Acid Therapeutics

Author:

Hong Sun Woo¹²,Jiang Yuanyuan²,Kim Soyoun²,Li Chiang J.³,Lee Dong-ki¹

Affiliation:

1. Global Research Laboratory for RNAi Medicine, Department of Chemistry, Sungkyunkwan University, Suwon, Korea.

2. Department of Biomedical Engineering, Dongguk University, Seoul, Korea.

3. Skip Ackerman Center for Molecular Therapeutics, Division of Gastroenterology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts.

Publisher

Mary Ann Liebert Inc

Subject

Drug Discovery,Genetics,Molecular Biology,Molecular Medicine,Biochemistry

Link

http://www.liebertpub.com/doi/pdf/10.1089/nat.2013.0466

Reference29 articles.

1. Egr1 Transcription Factor: Multiple Roles in Prostate Tumor Cell Growth and Survival

2. Target mRNA abundance dilutes microRNA and siRNA activity

3. The Efficacy of Small Interfering RNAs Targeted to the Type 1 Insulin-like Growth Factor Receptor (IGF1R) Is Influenced by Secondary Structure in the IGF1R Transcript

4. Origins and Mechanisms of miRNAs and siRNAs

5. RNAi in Human Cells

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