Chronic Empagliflozin Treatment Reduces Myocardial Infarct Size in Nondiabetic Mice Through STAT-3-Mediated Protection on Microvascular Endothelial Cells and Reduction of Oxidative Stress-Reference-Cited by-同舟云学术

Chronic Empagliflozin Treatment Reduces Myocardial Infarct Size in Nondiabetic Mice Through STAT-3-Mediated Protection on Microvascular Endothelial Cells and Reduction of Oxidative Stress

Published:2021-03-01 Issue:7 Volume:34 Page:551-571
ISSN:1523-0864
Container-title:Antioxidants & Redox Signaling
language:en
Short-container-title:Antioxidants & Redox Signaling

Author:

Nikolaou Panagiota Efstathia¹,Efentakis Panagiotis¹,Abu Qourah Fairouz¹,Femminò Saveria²,Makridakis Manousos³,Kanaki Zoi⁴,Varela Aimilia⁵,Tsoumani Maria¹,Davos Constantinos H.⁵,Dimitriou Constantinos A.⁵,Tasouli Androniki⁶,Dimitriadis George⁷,Kostomitsopoulos Nikolaos⁸,Zuurbier Coert J.⁹,Vlahou Antonia³,Klinakis Apostolos⁴,Brizzi Maria F.²,Iliodromitis Efstathios K.¹⁰,Andreadou Ioanna¹

Affiliation:

1. Laboratory of Pharmacology, Faculty of Pharmacy, National and Kapodistrian University of Athens, Athens, Greece.

2. Department of Medical Sciences, University of Turin, Turin, Italy.

3. Biotechnology Laboratory, Centre of Basic Research, Biomedical Research Foundation of the Academy of Athens (BRFAA), Athens, Greece.

4. Biomedical Research Foundation Academy of Athens, Athens, Greece.

5. Cardiovascular Research Laboratory, Biomedical Research Foundation Academy of Athens, Athens, Greece.

6. Onassis Cardiac Surgery Center, Athens, Greece.

7. 2nd Department of Internal Medicine, Research Institute and Diabetes Center, National and Kapodistrian University of Athens, “Attikon” University Hospital, Athens, Greece.

8. Academy of Athens Biomedical Research Foundation, Centre of Clinical Experimental Surgery and Translational Research, Athens, Greece.

9. Amsterdam UMC, University of Amsterdam, Laboratory of Experimental Intensive Care and Anesthesiology, Department of Anesthesiology, Amsterdam Cardiovascular Sciences, Amsterdam Infection & Immunity, Amsterdam, The Netherlands.

10. 2nd University Department of Cardiology, Medical School, National and Kapodistrian University of Athens, Athens, Greece.

Publisher

Mary Ann Liebert Inc

Subject

Cell Biology,Clinical Biochemistry,Molecular Biology,Physiology,Biochemistry,Cell Biology,Clinical Biochemistry,Molecular Biology,Physiology,Biochemistry

Link

https://www.liebertpub.com/doi/pdf/10.1089/ars.2019.7923

Reference74 articles.

1. VEGF-A/VEGFR2 signaling network in endothelial cells relevant to angiogenesis

2. SGLT2 inhibitors reduce infarct size in reperfused ischemic heart and improve cardiac function during ischemic episodes in preclinical models

3. Empagliflozin Limits Myocardial Infarction in Vivo and Cell Death in Vitro: Role of STAT3, Mitochondria, and Redox Aspects

4. Short-term statin administration in hypercholesterolaemic rabbits resistant to postconditioning: effects on infarct size, endothelial nitric oxide synthase, and nitro-oxidative stress

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