Time Is a Critical Factor When Evaluating Oligonucleotide Therapeutics in hERG Assays-Reference-Cited by-同舟云学术

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Time Is a Critical Factor When Evaluating Oligonucleotide Therapeutics in hERG Assays

Published:2023-04-01 Issue:2 Volume:33 Page:132-140
ISSN:2159-3337
Container-title:Nucleic Acid Therapeutics
language:en
Short-container-title:Nucleic Acid Therapeutics

Author:

Qu Yusheng¹^ORCID,Kirby Robert²,Davies Richard²,Jinat Ayesha²,Stabilini Stefano²,Wu Bin³,Yu Longchuan⁴,Gao BaoXi¹,Vargas Hugo M.¹

Affiliation:

1. Amgen Research, Translational Safety and Bioanalytical Sciences, Amgen, Inc., Thousand Oaks, California, USA.

2. Metrion Biosciences Ltd, Granta Center, Cambridge, United Kingdom.

3. Hybrid Modality Engineering, Amgen, Inc., Thousand Oaks, California, USA.

4. Cardiometabolic Disorders, Amgen, Inc., Thousand Oaks, California, USA.

Publisher

Mary Ann Liebert Inc

Subject

Drug Discovery,Genetics,Molecular Biology,Molecular Medicine,Biochemistry

Link

https://www.liebertpub.com/doi/pdf/10.1089/nat.2022.0043

Reference37 articles.

1. Advances in oligonucleotide drug delivery

2. The growth of siRNA-based therapeutics: Updated clinical studies

3. Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans

4. Functional anatomy of siRNAs for mediating efficient RNAi in Drosophila melanogaster embryo lysate

5. Preclinical and clinical development of siRNA-based therapeutics

Cited by 2 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Advanced In Vitro Screening of New Drugs for Proarrhythmic Activity;Genetic Engineering & Biotechnology News;2024-05-01

2. Scientific Review of the Proarrhythmic Risks of Oligonucleotide Therapeutics: Are Dedicated ICH S7B/E14 Studies Needed for Low‐Risk Modalities?;Clinical Pharmacology & Therapeutics;2024-02-16

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