Elevation of SHANK3 Levels by Antisense Oligonucleotides Directed Against the 3′-UTR of the Human SHANK3 mRNA
Author:
Affiliation:
1. Institute of Anatomy and Cell Biology and Ulm University, Ulm, Germany.
2. International Graduate School for Molecular Medicine, Ulm University, Ulm, Germany.
3. DZNE, Ulm Site, Ulm, Germany.
Publisher
Mary Ann Liebert Inc
Subject
Drug Discovery,Genetics,Molecular Biology,Molecular Medicine,Biochemistry
Link
https://www.liebertpub.com/doi/pdf/10.1089/nat.2022.0048
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1. ProSAP/Shank proteins - a family of higher order organizing molecules of the postsynaptic density with an emerging role in human neurological disease
2. Proline-Rich Synapse-Associated Proteins ProSAP1 and ProSAP2 Interact with Synaptic Proteins of the SAPAP/GKAP Family
3. Mutations in the gene encoding the synaptic scaffolding protein SHANK3 are associated with autism spectrum disorders
4. The PSD protein ProSAP2/Shank3 displays synapto-nuclear shuttling which is deregulated in a schizophrenia-associated mutation
5. The 22q13.3 Deletion Syndrome (Phelan-McDermid Syndrome)
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