Establishment of a Coculture Model for Studying Inflammation After Pediatric Cardiopulmonary Bypass: from Bench to Bedside-Reference-Cited by-同舟云学术

Establishment of a Coculture Model for Studying Inflammation After Pediatric Cardiopulmonary Bypass: from Bench to Bedside

Published:2012-06 Issue:6 Volume:32 Page:269-276
ISSN:1079-9907
Container-title:Journal of Interferon & Cytokine Research
language:en
Short-container-title:Journal of Interferon & Cytokine Research

Author:

Wollersheim Sonja¹,Fedarava Katisaryna²,Huebler Michael³,Schneiderhan-Marra Nicole⁴,Berger Felix¹,Miera Oliver¹,Schmitt Katharina R.¹

Affiliation:

1. Department of Congenital Heart Disease/Pediatric Cardiology, Deutsches Herzzentrum Berlin, Berlin, Germany.

2. Department of Anesthesia, Deutsches Herzzentrum Berlin, Berlin, Germany.

3. Department of Cardiothoracic and Vascular Surgery, Deutsches Herzzentrum Berlin, Berlin, Germany.

4. Department of Biochemistry, NMI Natural and Medical Sciences Institute at the University of Tübingen, Reutlingen, Germany.

Publisher

Mary Ann Liebert Inc

Subject

Virology,Cell Biology,Immunology

Link

http://www.liebertpub.com/doi/pdf/10.1089/jir.2011.0096

Reference27 articles.

1. Perioperative Serum Interleukins in Neonates With Hypoplastic Left-Heart Syndrome and Transposition of the Great Arteries

2. Decreased exhaled nitric oxide may be a marker of cardiopulmonary bypass–induced injury

3. Endothelial Cell Injury in Cardiovascular Surgery: The Systemic Inflammatory Response11Recent discoveries in the field of vascular biology have led to an expanded understanding of the pathogenesis of many of the immediate and long-term complications of patients undergoing cardiovascular operations and interventional cardiologic procedures. In particular, the vascular endothelium has emerged as the central focus of many of the biologic events that affect the preoperative, operative, and postoperative course of nearly all heart surgery patients. A recurring theme in the study of endothelial cell biology is the crucial role that endothelial cell injury plays in the difficulties that our patients encounter. The deleterious effects of endothelial cell injury are most evident in the acute syndromes of vasospasm, coagulopathy, ischemia/reperfusion injury, and the systemic inflammatory response to cardiopulmonary bypass. In addition, chronic endothelial cell injury contributes to the development of anastomotic narrowing and the progression of atherosclerosis, both of which limit the long-term success of coronary artery bypass grafting. Because of the increasingly recognized role of the endothelium in cardiovascular function there is a tremendous amount of basic science information detailing the response of the endothelium to injury. This is the fifth in a series of seven reviews intended as an introduction to the major topics of endothelial cell biology that are of importance to the practicing cardiothoracic surgeon. In particular, the authors have focused on the role that the endothelium has on the development of vasomotor dysfunction, bleeding and thrombosis, neutrophil-endothelial cell interaction, and obstructive arteriopathy. The aim of these reviews is to provide a concise reference point for cardiothoracic surgeons as they evaluate the ever-accumulating research findings and new therapies that stem from the study of the endothelium in response to the insults encountered in cardiothoracic surgery.Edward D. Verrier, MD

4. Randomized Comparison Between Normothermic and Hypothermic Cardiopulmonary Bypass in Pediatric Open-Heart Surgery

5. Hypothermia downregulates inflammation but enhances IL-6 secretion by stimulated endothelial cells

Cited by 2 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Deep hypothermia therapy attenuates LPS-induced microglia neuroinflammation via the STAT3 pathway;Neuroscience;2017-09

2. Hypothermia During Cardiopulmonary Bypass Increases Need for Inotropic Support but Does Not Impact Inflammation in Children Undergoing Surgical Ventricular Septal Defect Closure;Artificial Organs;2015-11-19