Adoptive Cell Therapy for Patients with Melanoma, Using Tumor-Infiltrating Lymphocytes Genetically Engineered to Secrete Interleukin-2-Reference-Cited by-同舟云学术

Adoptive Cell Therapy for Patients with Melanoma, Using Tumor-Infiltrating Lymphocytes Genetically Engineered to Secrete Interleukin-2

Published:2008-05 Issue:5 Volume:19 Page:496-510
ISSN:1043-0342
Container-title:Human Gene Therapy
language:en
Short-container-title:Human Gene Therapy

Author:

Heemskerk Bianca¹,Liu Ke¹²,Dudley Mark. E.¹,Johnson Laura A.¹,Kaiser Andrew¹,Downey Stephanie¹,Zheng Zhili¹,Shelton Thomas E.¹,Matsuda Kant³,Robbins Paul F.¹,Morgan Richard A.¹,Rosenberg Steven A.¹

Affiliation:

1. Surgery Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892.

2. U.S. Food and Drug Administration, Rockville, MD 20852.

3. Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892.

Publisher

Mary Ann Liebert Inc

Subject

Genetics,Molecular Biology,Molecular Medicine

Link

http://www.liebertpub.com/doi/pdf/10.1089/hum.2007.0171

Reference33 articles.

1. IL-2 administration increases CD4+CD25hi Foxp3+ regulatory T cells in cancer patients

2. CD8+T Cell Immunity Against a Tumor/Self-Antigen Is Augmented by CD4+T Helper Cells and Hindered by Naturally Occurring T Regulatory Cells

3. Human T lymphocytes transduced by lentiviral vectors in the absence of TCR activation maintain an intact immune competence

4. Cancer Regression and Autoimmunity in Patients After Clonal Repopulation with Antitumor Lymphocytes

5. A Phase I Study of Nonmyeloablative Chemotherapy and Adoptive Transfer of Autologous Tumor Antigen-Specific T Lymphocytes in Patients With Metastatic Melanoma

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