Long-Term Evaluation of a Phase 1 Study of AADC Gene Therapy for Parkinson's Disease-Reference-Cited by-同舟云学术

Long-Term Evaluation of a Phase 1 Study of AADC Gene Therapy for Parkinson's Disease

Published:2012-04 Issue:4 Volume:23 Page:377-381
ISSN:1043-0342
Container-title:Human Gene Therapy
language:en
Short-container-title:Human Gene Therapy

Author:

Mittermeyer Gabriele¹,Christine Chadwick W.²,Rosenbluth Kathryn H.¹,Baker Suzanne L.³,Starr Philip¹,Larson Paul¹,Kaplan Paul L.⁴,Forsayeth John¹,Aminoff Michael J.²,Bankiewicz Krystof S.¹

Affiliation:

1. Department of Neurological Surgery, University of California San Francisco (UCSF), San Francisco, CA 94143.

2. Department of Neurology, University of California San Francisco (UCSF), San Francisco, CA 94143.

3. Helen Wills Neuroscience Institute, University of California Berkeley, Berkeley, CA 94720.

4. Genzyme Corporation, 500 Kendall Street, Cambridge, MA 02142.

Publisher

Mary Ann Liebert Inc

Subject

Genetics,Molecular Biology,Molecular Medicine

Link

http://www.liebertpub.com/doi/pdf/10.1089/hum.2011.220

Reference21 articles.

1. Subregional 6-[18F]fluoro-ʟ-m-tyrosine Uptake in the Striatum in Parkinson's Disease

2. Convection-Enhanced Delivery of AAV Vector in Parkinsonian Monkeys; In Vivo Detection of Gene Expression and Restoration of Dopaminergic Function Using Pro-drug Approach

3. Long-Term Clinical Improvement in MPTP-Lesioned Primates after Gene Therapy with AAV-hAADC

4. Safety and tolerability of putaminal AADC gene therapy for Parkinson disease

5. Biodistribution of Adeno-associated Virus Type-2 in Nonhuman Primates after Convection-enhanced Delivery to Brain

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