Cardiac Gene Transfer of Short Hairpin RNA Directed Against Phospholamban Effectively Knocks Down Gene Expression but Causes Cellular Toxicity in Canines-Reference-Cited by-同舟云学术

Cardiac Gene Transfer of Short Hairpin RNA Directed Against Phospholamban Effectively Knocks Down Gene Expression but Causes Cellular Toxicity in Canines

Published:2011-08 Issue:8 Volume:22 Page:969-977
ISSN:1043-0342
Container-title:Human Gene Therapy
language:en
Short-container-title:Human Gene Therapy

Author:

Bish Lawrence T.¹,Sleeper Meg M.²,Reynolds Caryn²,Gazzara Jeffrey¹,Withnall Elanor²,Singletary Gretchen E.²,Buchlis George³,Hui Daniel³,High Katherine A.³,Gao Guangping⁴,Wilson James M.⁵,Sweeney H. Lee¹

Affiliation:

1. Department of Physiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104.

2. Section of Cardiology, Department of Clinical Studies, Veterinary Hospital of the University of Pennsylvania, Philadelphia, PA 19104.

3. Division of Hematology and Center for Cellular and Molecular Therapeutics, Children's Hospital of Philadelphia, and Howard Hughes Medical Institute, Philadelphia, PA 19104.

4. Department of Molecular Genetics and Microbiology, Gene Therapy Center, University of Massachusetts School of Medicine, Worcester, MA 01605.

5. Division of Medical Genetics, Gene Therapy Program, University of Pennsylvania School of Medicine, Translational Research Laboratory, Philadelphia, PA 19104.

Publisher

Mary Ann Liebert Inc

Subject

Genetics,Molecular Biology,Molecular Medicine

Link

http://www.liebertpub.com/doi/pdf/10.1089/hum.2011.035

Reference50 articles.

1. AAV-mediated knockdown of phospholamban leads to improved contractility and calcium handling in cardiomyocytes

2. Percutaneous Transendocardial Delivery of Self-complementary Adeno-associated Virus 6 Achieves Global Cardiac Gene Transfer in Canines

3. Percutaneous Transendocardial Delivery of Self-Complementary Adeno-Associated Virus 6 in the Canine

4. MicroRNA-208a is a regulator of cardiac hypertrophy and conduction in mice

5. MicroRNA-133 controls cardiac hypertrophy

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