Clonal Inventory Screens Uncover Monoclonality Following Serial Transplantation ofMGMTP140K-Transduced Stem Cells and Dose-Intense Chemotherapy-Reference-Cited by-同舟云学术

Clonal Inventory Screens Uncover Monoclonality Following Serial Transplantation ofMGMTP140K-Transduced Stem Cells and Dose-Intense Chemotherapy

Published:2011-06 Issue:6 Volume:22 Page:697-710
ISSN:1043-0342
Container-title:Human Gene Therapy
language:en
Short-container-title:Human Gene Therapy

Author:

Giordano Frank A.¹,Sorg Ursula R.²,Appelt Jens-Uwe¹,Lachmann Nico³,Bleier Stephanie⁴,Roeder Ingo⁵,Kleff Veronika⁶,Flasshove Michael⁷,Zeller W. Jens⁴,Allgayer Heike⁴,Kalle Christof von¹,Fruehauf Stefan⁸,Moritz Thomas³,Laufs Stephanie¹

Affiliation:

1. Translational Oncology, National Center for Tumor Diseases and German Cancer Research Center, Heidelberg 69120, Germany.

2. Institute for Medical Microbiology and Hospital Hygiene, University of Dusseldorf, Dusseldorf 40225, Germany.

3. REBIRTH Center-of-Excellence, Reprogramming Group, Hannover Medical School, Hannover 30625, Germany.

4. Clinical Cooperation Unit Molecular Oncology of Solid Tumors, German Cancer Research Center, Heidelberg 69120, Germany.

5. Institute for Medical Informatics and Biometry, Medical Faculty Carl Gustav Carus, Dresden University of Technology, Dresden 01307, Germany.

6. Institute of Anatomy, University of Duisburg-Essen Medical School, Essen 45122, Germany.

7. University of Duisburg-Essen Medical School, Department of Internal Medicine (Cancer Research), Essen, Germany.

8. Center for Tumor Diagnostics and Therapy, Paracelsus Hospital, Osnabrueck 49076, Germany.

Publisher

Mary Ann Liebert Inc

Subject

Genetics,Molecular Biology,Molecular Medicine

Link

http://www.liebertpub.com/doi/pdf/10.1089/hum.2010.088

Reference67 articles.

1. Evidence that the number of hematopoietic stem cells per animal is conserved in mammals

2. Gene Therapy for Immunodeficiency Due to Adenosine Deaminase Deficiency

3. Correction of ADA-SCID by Stem Cell Gene Therapy Combined with Nonmyeloablative Conditioning

4. QuickMap: a public tool for large-scale gene therapy vector insertion site mapping and analysis

5. Stable differentiation and clonality of murine long-term hematopoiesis after extended reduced-intensity selection for MGMT P140K transgene expression

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