Deneysel Meme Kanseri Modelinde Pistacia terebinthus L. Subsp palaestina ve Rhus coriaria L. Bitkilerinin Beyin Dokusunun Bazı Biyokimyasal Parametreleri Üzerindeki Etkileri

Abstract

In this study, the biochemical effects of Pistacia terebinthus L. subsp Palaestina (terebinth) and Rhus coriaria L (sumac) plants on DMBA-induced breast cancer in female 66 Sprague-Dawley rats were investigated. In biochemical studies, total protein, MDA, GSH, fatty acid and vitamin levels and changes in activities of CAT, GST and SOD which are antioxidant enzymes in brain tissue was examined. Total protein levels generally reduced in DMBA group than control. While the levels of MDA in DMBA groups of brain tissue incremented compared to the control group; reduced in antioxidant groups.Cholesterol levels and lipophilic vitamins were determined by HPLC. The grades of their were dissimilar in DMBA and antioxidant groups of samples. Fatty acids were analyzed by GC. As a result of analysis, acids such as palmitic, palmitoleic, stearic, oleic, linoleic, arachidonic, docosahexaenoic were found to be high in tissues. These fatty acid levels showed different changes in DMBA and antioxidant groups of tissues. These datas approve the use of Pistacia terebinthus and Rhus coriaria plants as a application against breast cancer and its adversity and recommend it is suitable to maintain studies for its safe medicinal application.