Affiliation:
1. Institute of Toxicology, Saint-Petersburg, Russia; St. Petersburg State Pediatric Medical University, Saint-Petersburg, Russia
2. Institute of Toxicology, Saint-Petersburg, Russia
Abstract
Ten biochemical parameters total protein, albumin, glucose, cholesterol, urea, creatinine, total bilirubin, ALT, AST, APh were determined during long-term light mode changes in serum of rats. Changing the light mode, a number of parameters revealed unreliable 24-hour rhythms. An ultradian 12-hour reliable rhythm has been for serum total protein of rats exposed to constant darkness during 1 month. The light-modified model can be used to study the effects of the chemical factor in combination with the physical factor of the external environment, as well as in preclinical toxicity tests of medicinal substances in different light modes.
Publisher
Institute of Biochemistry
Subject
General Biochemistry, Genetics and Molecular Biology,General Medicine
Cited by
3 articles.
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