Author:
Zhou Yi,Yuan Guandou,Zhong Fudi,He Songqing
Abstract
Alcohol-induced liver disease (ALD) is a complex disorder, with a disease spectrum ranging from steatosis to steatohepatitis, cirrhosis, and hepatocellular carcinoma. Although the pathogenesis of ALD is incompletely understood and currently no effective drugs are available for ALD, several lines of evidence suggest that complement activation and oxidative stress play crucial roles in the pathogenesis of ALD. Complement activation can regulate the production of ROS and influence oxidative stress in ALD. Precise regulation of the complement system in ALD may be a rational and novel avenue to postpone and even reverse the progression of disease and simultaneously promote the repair of liver injury. In this mini-review, we briefly summarize the recent research progress, especially focusing on the role of complement and oxidative stress-induced transfer RNA-derived fragments, which might help us to better understand the pathogenesis of ALD and provide aid in the development of novel therapeutic strategies for ALD.
Funder
National Natural Science Foundation of China
The 111 Project
Guangxi Key Research and Development Plan
Guangxi BaGui Scholars
Molecular Medicine of Liver Injury and Repair Collaborative Innovation Center
Guangxi Key Laboratory of Molecular Medicine in Liver Injury and Repair
Special projects of local science and technology development guided by the central government
Publisher
The Korean Association for the Study of the Liver
Subject
Molecular Biology,Hepatology
Cited by
11 articles.
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